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Richard Wooster Selected Research

GSK 1070916

1/2016Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.
7/2011High chromosome number in hematological cancer cell lines is a negative predictor of response to the inhibition of Aurora B and C by GSK1070916.

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Richard Wooster Research Topics

Disease

34Neoplasms (Cancer)
01/2022 - 05/2002
5Breast Neoplasms (Breast Cancer)
01/2017 - 05/2002
5Lung Neoplasms (Lung Cancer)
02/2013 - 12/2002
4X-Linked Mental Retardation (Mental Retardation, X Linked)
09/2007 - 12/2006
2Small Cell Lung Carcinoma (Small Cell Lung Cancer)
11/2019 - 01/2019
2Neuroblastoma
02/2013 - 04/2010
2Colonic Neoplasms (Colon Cancer)
03/2012 - 05/2010
2Melanoma (Melanoma, Malignant)
12/2002 - 06/2002
1COVID-19
01/2022
1Human Influenza (Influenza)
01/2022
1Ciliary Motility Disorders (Primary Ciliary Dyskinesia)
01/2022
1Communicable Diseases (Infectious Diseases)
01/2022
1Hyperglycemia
01/2020
1Neuroendocrine Carcinoma
11/2019
1Neuroendocrine Tumors (Neuroendocrine Tumor)
01/2019
1Carcinoma (Carcinomatosis)
02/2013
1Hematologic Neoplasms (Hematological Malignancy)
03/2012
1Hepatocellular Carcinoma (Hepatoma)
01/2012
1Chromosomal Instability (Chromosome Stability)
07/2010
1Tetraploidy
07/2010
1Neoplasm Metastasis (Metastasis)
10/2009
1Intellectual Disability (Idiocy)
05/2007
1Anodontia (Hypodontia)
02/2007
1Megalencephaly
02/2007
1Seizures (Absence Seizure)
02/2007
1Tremor (Tremors)
02/2007
1Hypogonadism (Hypergonadotropic Hypogonadism)
02/2007
1Abdominal Obesity
02/2007
1Talipes Cavus (Pes Cavus)
02/2007
1Glioma (Gliomas)
04/2006
1Seminoma
01/2006
1Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
01/2006
1Aneuploidy (Aneuploid)
01/2006
1Adenocarcinoma
09/2004
1Urinary Bladder Neoplasms (Bladder Cancer)
02/2004
1Transitional Cell Carcinoma
02/2004
1Prostatic Neoplasms (Prostate Cancer)
02/2003
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
12/2002
1Colorectal Neoplasms (Colorectal Cancer)
11/2002

Drug/Important Bio-Agent (IBA)

12Proteins (Proteins, Gene)FDA Link
01/2022 - 02/2004
12DNA (Deoxyribonucleic Acid)IBA
10/2011 - 05/2002
10Phosphotransferases (Kinase)IBA
01/2016 - 11/2002
7Pharmaceutical PreparationsIBA
01/2020 - 11/2006
6Biomarkers (Surrogate Marker)IBA
02/2013 - 07/2010
6Protein Kinases (Protein Kinase)IBA
03/2007 - 09/2004
3Messenger RNA (mRNA)IBA
01/2022 - 02/2004
3GSK923295IBA
01/2016 - 04/2010
3Complementary DNA (cDNA)IBA
02/2004 - 05/2002
2LigandsIBA
01/2020 - 10/2009
2somatostatin receptor 2IBA
11/2019 - 01/2019
2Aurora KinasesIBA
01/2016 - 07/2011
2GSK 1070916IBA
01/2016 - 07/2011
2Mitogen-Activated Protein KinasesIBA
02/2013 - 11/2002
2Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
10/2009 - 11/2002
2Amino AcidsFDA Link
02/2007 - 11/2002
1Lipid NanoparticlesIBA
01/2022
1VaccinesIBA
01/2022
1copanlisibIBA
01/2020
1Caspase 3 (Caspase-3)IBA
11/2019
1Peptides (Polypeptides)IBA
01/2019
1Drug CombinationsIBA
02/2013
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
02/2013
1MitogensIBA
02/2013
1Antineoplastic Agents (Antineoplastics)IBA
11/2012
1ProteomeIBA
11/2012
1trametinibIBA
03/2012
1Cytostatic AgentsIBA
03/2012
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2012
1TensinsIBA
01/2012
1Fatty Acid Synthases (Fatty Acid Synthase)IBA
01/2012
1GSK 461364IBA
12/2011
1GSK 461364AIBA
07/2010
1Phenobarbital (Luminal)FDA Link
05/2010
1MTOR InhibitorsIBA
05/2010
1Inosine Monophosphate (IMP)IBA
04/2010
1Oxidoreductases (Dehydrogenase)IBA
04/2010
1Small Interfering RNA (siRNA)IBA
04/2010
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
10/2009
1GSK 1363089IBA
10/2009
1Tyrosine (L-Tyrosine)FDA Link
10/2009
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
10/2009
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2009
1Proto-Oncogene Proteins c-metIBA
10/2009
1Lapatinib (GW572016)FDA Link
04/2008
1TransferasesIBA
05/2007
1EctodysplasinsIBA
02/2007
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
02/2007
1UbiquitinIBA
02/2007
1Nonsense Codon (Nonsense Mutation)IBA
12/2006
1Temozolomide (Temodar)FDA LinkGeneric
04/2006
1Alkylating AgentsIBA
04/2006
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2006
1Mutant Proteins (Protein, Mutant)IBA
09/2005
1CarcinogensIBA
09/2005
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
09/2004
1EnzymesIBA
09/2004
1Codon (Codons)IBA
12/2002

Therapy/Procedure

9Therapeutics
11/2019 - 12/2002
2Drug Therapy (Chemotherapy)
07/2010 - 04/2006
1Radiotherapy
04/2006